PREVIOUS PUBLICATIONS
Deciphering cell-cell communication in the developing mammalian brain. Yuzwa SA, Miller FD. Neurogenesis (Austin). 2017 Feb 6;4(1):e1286425
A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis. Seong BK, Fathers KE, Hallett R, Yung CK, Stein LD, Mouaaz S, Kee L, Hawkins CE, Irwin MS, Kaplan DR. Cancer Res. 2017 Feb 1;77(3):696-706. doi: 10.1158/0008-5472.CAN-16-1502. Epub 2016 Nov 29
Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Voronova A, Yuzwa SA, Wang BS, Zahr S, Syal C, Wang J, Kaplan DR, Miller FD. Neuron. 2017 May 3;94(3):500-516
A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. Feinberg K., Kolaj A., Rubin L., Miller F.D., and Kaplan D.R. (2017) J. Cell Biol. 216:3655-3675.
Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling. Yuzwa SA, Borrett MJ, Innes BT, Voronova A, Ketela T, Kaplan DR, Bader GD, Miller FD. Cell Rep. 2017 Dec 26;21(13):3970-3986
A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human. Bernard-Gauthier V, Bailey JJ, Mossine AV, Lindner S, Vomacka L, Aliaga A, Shao X, Quesada CA, Sherman P, Mahringer A, Kostikov A, Grand’Maison M, Rosa-Neto P, Soucy JP, Thiel A, Kaplan DR, Fricker G, Wängler B, Bartenstein P, Schirrmacher R, Scott PJH. J Med Chem. 2017 Aug 24;60(16):6897-6910
RNAi screen identifies essential regulators of human brain metastasis-initiating cells. Singh M, Venugopal C, Tokar T, Brown KR, McFarlane N, Bakhshinyan D, Vijayakumar T, Manoranjan B, Mahendram S, Vora P, Qazi M, Dhillon M, Tong A, Durrer K, Murty N, Hallet R, Hassell JA, Kaplan DR, Cutz JC, Jurisica I, Moffat J, Singh SK. Acta Neuropathol. 2017 Dec;134(6):923-940
Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation. Ravindran E, Hu H, Yuzwa SA, Hernandez-Miranda LR, Kraemer N, Ninnemann O, Musante L, Boltshauser E, Schindler D, Hübner A, Reinecker HC, Ropers HH, Birchmeier C, Miller FD, Wienker TF, Hübner C, Kaindl AM. PLoS Genet. 2017 Apr 28;13(4):e1006746
2016 PUBLICATIONS
Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip. Johnston AP, Yuzwa SA, Carr MJ, Mahmud N, Storer MA, Krause MP, Jones K, Paul S, Kaplan DR, Miller FD. Cell Stem Cell. 2016 Oct 6;19(4):433-448.
Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma. Lun X, Wells JC, Grinshtein N, King JC, Hao X, Dang NH, Wang X, Aman A, Uehling D, Datti A, Wrana JL, Easaw JC, Luchman A, Weiss S, Cairncross JG, Kaplan DR, Robbins SM, Senger DL. Clin Cancer Res. 2016 Aug 1;22(15):3860-75.
Identification of drugs that regulate dermal stem cells and enhance skin repair. Naska, S., Yuzwa, S.A. (co-first author), Johnston, A.P.W., Paul, S., Paul, S., Smith, K., Paris, M., Sefton, M.V., Datti, A., Miller, F.D., and Kaplan, D.R. (2016) Stem Cell Reports 6(1):74-84.
A Glo1-methylglyoxal pathway that is perturbed in maternal diabetes regulates embryonic and adult neural stem cell pools in murine offspring. Yang G., Cancino G.I., Zahr S.K., Guskjolen A., Voronova A., Gallagher D., Frankland P.W., Kaplan D.R., and Miller F.D. (2016) Cell Reports 17, 1022-1036.
Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma. Hallett RM, Seong AB, Kaplan DR, Irwin MS. Mol Oncol. 2016 Nov;10(9):1461-1472.
Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks. Yuzwa SA, Yang G, Borrett MJ, Clarke G, Cancino GI, Zahr SK, Zandstra PW, Kaplan DR, Miller FD. Neuron. 2016 Sep 7;91(5):988-1004
Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells. Grinshtein N, Rioseco CC, Marcellus R, Uehling D, Aman A, Lun X, Muto O, Podmore L, Lever J, Shen Y, Blough MD, Cairncross GJ, Robbins SM, Jones SJ, Marra MA, Al-Awar R, Senger DL, Kaplan DR. Oncotarget. 2016 Sep 13;7(37):59360-59376.
In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations. Bamba Y, Shofuda T, Kato M, Pooh RK, Tateishi Y, Takanashi J, Utsunomiya H, Sumida M, Kanematsu D, Suemizu H, Higuchi Y, Akamatsu W, Gallagher D, Miller FD, Yamasaki M, Kanemura Y, Okano H. Mol Brain. 2016 Jul 19;9(1):70.
2015 PUBLICATIONS
Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. Gallagher D, Voronova A, Zander MA, Cancino GI, Bramall A, Krause MP, Abad C, Tekin M, Neilsen PM, Callen DF, Scherer SW, Keller GM, Kaplan DR, Walz K, Miller FD. Dev Cell. 2015 Jan 12;32(1):31-42
Schwann cells generated from neonatal skin-derived precursors or neonatal peripheral nerve improve functional recovery after acute transplantation into the partially injured cervical spinal cord of the rat. Sparling JS, Bretzner F, Biernaskie J, Assinck P, Jiang Y, Arisato H, Plunet WT, Borisoff J, Liu J, Miller FD, Tetzlaff W. J Neurosci. 2015 Apr 29;35(17):6714-30
Axon diameter and axonal transport: In vivo and in vitro effects of androgens. Pesari, M., Soon-Shiong, R., French, L., Kaplan, D.R., Miller, F.D., and Paus, T. (2015) NeuroImage 115, 191-201.
Activating endogenous neural precursor cells using metformin leads to neural repair and functional recovery in a model of childhood brain injury. Dadwal P., Mahmud N., Sinai L., Azimi A., Fatt M., Wondisford F., Miller F.D., and Morshead C.M. (2015) Stem Cell Reports 5, 166-173.
Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development. Badouel C, Zander MA, Liscio N, Bagherie-Lachidan M, Sopko R, Coyaud E, Raught B, Miller FD, McNeill H. Development. 2015 Aug 15;142(16):2781-91.
Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system. Cancino GI, Fatt MP, Miller FD, Kaplan DR. Cell Cycle. 2015;14(20):3270-81.
A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis. Amadei G, Zander MA, Yang G, Dumelie JG, Vessey JP, Lipshitz HD, Smibert CA, Kaplan DR, Miller FD. J Neurosci. 2015 Nov 25;35(47):15666-81.
Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation. Fatt M, Hsu K, He L, Wondisford F, Miller FD, Kaplan DR, Wang J. Stem Cell Reports. 2015 Dec 8;5(6):988-995.
Prokineticin signaling is required for the maintenance of a de novo population of c-KIT⁺ cells to sustain neuroblastoma progression. Lau ST, Hansford LM, Chan WK, Chan GC, Wan TS, Wong KK, Kaplan DR, Tam PK, Ngan ES. Oncogene. 2015 Feb 19;34(8):1019-34.
2014 PUBLICATIONS
Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma. Wolter JK, Wolter NE, Blanch A, Partridge T, Cheng L, Morgenstern DA, Podkowa M, Kaplan DR, Irwin MS. Oncotarget. 2014 Jan 15;5(1):161-72.
CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development. Tsui D, Voronova A, Gallagher D, Kaplan DR, Miller FD, Wang J. Dev Biol. 2014 Jan 15;385(2):230-41.
Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. Dixit R, Wilkinson G, Cancino GI, Shaker T, Adnani L, Li S, Dennis D, Kurrasch D, Chan JA, Olson EC, Kaplan DR, Zimmer C, Schuurmans C. J Neurosci. 2014 Jan 8;34(2):539-53.
Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development. Zander MA, Burns SE, Yang G, Kaplan DR, Miller FD. J Neurosci. 2014 Apr 9;34(15):5164-75.
Direct genesis of functional rodent and human schwann cells from skin mesenchymal precursors. Krause MP, Dworski S, Feinberg K, Jones K, Johnston AP, Paul S, Paris M, Peles E, Bagli D, Forrest CR, Kaplan DR, Miller FD. Stem Cell Reports. 2014 Jun 19;3(1):85-100.
p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells. Fatt MP, Cancino GI, Miller FD, Kaplan DR. Cell Death Differ. 2014 Oct;21(10):1546-59.
The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life. Zander MA, Cancino GI, Gridley T, Kaplan DR, Miller FD. PLoS One. 2014 Aug 19;9(8):e104767. doi: 10.1371/journal.pone.0104767. eCollection 2014.
TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival. Chavali PL, Saini RK, Zhai Q, Vizlin-Hodzic D, Venkatabalasubramanian S, Hayashi A, Johansson E, Zeng ZJ, Mohlin S, Påhlman S, Hansford L, Kaplan DR, Funa K. Cell Death Dis. 2014 Oct 30;5:e1502.
An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Yang G, Smibert CA, Kaplan DR, Miller FD. Neuron. 2014 Nov 19;84(4):723-39.
2013 PUBLICATIONS
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer’s disease. Cancino G.I., Miller F.D., and Kaplan D.R. (2013) Neurobiol. Aging 34, 387-399.
FoxP2 regulates neurogenesis during embryonic cortical development. Tsui D, Vessey JP, Tomita H, Kaplan DR, Miller FD. J Neurosci. 2013 Jan 2;33(1):244-58.
A Novel Neurofibromin (NF1) interaction with the Leucine Rich Pentatrico Peptide Repeat motif-Containing (LRPPRC) Protein links Neurofibromatosis Type 1 and the French Canadian variant of Leigh’s Syndrome in a common molecular complex. Arun, V., Wiley, J., Kaur, H., Kaplan, D.R., and A. Guha. (2013) J. Neurosci. Res. 91:494-505.
Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes. Arun V, Worrell L, Wiley JC, Kaplan DR, Guha A. FEBS Lett. 2013 May 21;587(10):1466-73.
A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines. Vojvodic M, Hansford LM, Morozova O, Blakely KM, Taylor P, Fathers KE, Moffat J, Marra M, Smith KM, Moran MF, Kaplan DR. Curr Drug Discov Technol. 2013 Dec;10(4):283-304.
p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior. Cancino GI, Yiu AP, Fatt MP, Dugani CB, Flores ER, Frankland PW, Josselyn SA, Miller FD, Kaplan DR. J Neurosci. 2013 Jul 31;33(31):12569-85
Sox2-mediated regulation of adult neural crest precursors and skin repair. Johnston AP, Naska S, Jones K, Jinno H, Kaplan DR, Miller FD. Stem Cell Reports. 2013 Jun 4;1(1):38-45
Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway. Gallagher D, Norman AA, Woodard CL, Yang G, Gauthier-Fisher A, Fujitani M, Vessey JP, Cancino GI, Sachewsky N, Woltjen K, Fatt MP, Morshead CM, Kaplan DR, Miller FD. Cell Stem Cell. 2013 Nov 7;13(5):564-76
Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma. Haftchenary S, Luchman HA, Jouk AO, Veloso AJ, Page BD, Cheng XR, Dawson SS, Grinshtein N, Shahani VM, Kerman K, Kaplan DR, Griffin C, Aman AM, Al-Awar R, Weiss S, Gunning PT. ACS Med Chem Lett. 2013 Sep 8;4(11):1102-7
Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV. Wang PY, Currier MA, Hansford L, Kaplan D, Chiocca EA, Uchida H, Goins WF, Cohen JB, Glorioso JC, van Kuppevelt TH, Mo X, Cripe TP. Gene Ther. 2013 Jul;20(7):761-9
2012 PUBLICATIONS
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice. Uribe V, Wong BK, Graham RK, Cusack CL, Skotte NH, Pouladi MA, Xie Y, Feinberg K, Ou Y, Ouyang Y, Deng Y, Franciosi S, Bissada N, Spreeuw A, Zhang W, Ehrnhoefer DE, Vaid K, Miller FD, Deshmukh M, Howland D, Hayden MR. Hum Mol Genet. 2012 May 1;21(9):1954-67.
Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Wang J, Gallagher D, DeVito LM, Cancino GI, Tsui D, He L, Keller GM, Frankland PW, Kaplan DR, Miller FD. Cell Stem Cell. 2012 Jul 6;11(1):23-35
An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells. Vessey JP, Amadei G, Burns SE, Kiebler MA, Kaplan DR, Miller FD. Cell Stem Cell. 2012 Oct 5;11(4):517-28
Mobilizing endogenous stem cells for repair and regeneration: are we there yet? Miller FD, Kaplan DR. Cell Stem Cell. 2012 Jun 14;10(6):650-2.
2011 PUBLICATIONS
Endogenous microglia regulate development of embryonic cortical precursor cells. Antony J.M., Paquin A., Nutt S.L., Kaplan D.R., and Miller F.D. (2011) J. Neurosci. Res. 89, 286-298.
Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis. Raj B, O’Hanlon D, Vessey JP, Pan Q, Ray D, Buckley NJ, Miller FD, Blencowe BJ. Mol Cell. 2011 Sep 2;43(5):843-50.
Directed differentiation of skin-derived precursors into functional vascular smooth muscle cells. Steinbach SK, El-Mounayri O, DaCosta RS, Frontini MJ, Nong Z, Maeda A, Pickering JG, Miller FD, Husain M. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2938-48.
Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition. Castelo-Branco P, Zhang C, Lipman T, Fujitani M, Hansford L, Clarke I, Harley CB, Tressler R, Malkin D, Walker E, Kaplan DR, Dirks P, Tabori U. Clin Cancer Res. 2011 Jan 1;17(1):111-21.
Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Grinshtein N, Datti A, Fujitani M, Uehling D, Prakesch M, Isaac M, Irwin MS, Wrana JL, Al-Awar R, Kaplan DR. Cancer Res. 2011 Feb 15;71(4):1385-95.
Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins. Chung J, Grant RI, Kaplan DR, Irwin MS. J Biol Chem. 2011 Nov 25;286(47):40671-80.
2010 PUBLICATIONS
CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain. Wang J, Weaver IC, Gauthier-Fisher A, Wang H, He L, Yeomans J, Wondisford F, Kaplan DR, Miller FD. Dev Cell. 2010 Jan 19;18(1):114-25.
p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain. Park KJ, Grosso CA, Aubert I, Kaplan DR, Miller FD. Nat Neurosci. 2010 May;13(5):559-66.
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, Kaplan DR, Miller FD, Mak TW. Genes Dev. 2010 Mar 15;24(6):549-60.
The use of immobilized neurotrophins to support neuron survival and guide nerve fiber growth in compartmentalized chambers. Yu L.M.Y., Miller F.D., and Shoichet M.S. (2010) Biomaterials 31, 6987-6999.
p75NTR is an obligate signalling receptor required for cues that cause sympathetic neuron growth cone collapse. Naska S., Lin D.C., Miller F.D., and Kaplan D.R. (2010) Mol. Cell. Neurosci. 45, 108-120.
Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. Smith KM, Datti A, Fujitani M, Grinshtein N, Zhang L, Morozova O, Blakely KM, Rotenberg SA, Hansford LM, Miller FD, Yeger H, Irwin MS, Moffat J, Marra MA, Baruchel S, Wrana JL, Kaplan DR. EMBO Mol Med. 2010 Sep;2(9):371-84.
Coffin-Lowry syndrome: a role for RSK2 in mammalian neurogenesis. Dugani CB, Paquin A, Kaplan DR, Miller FD. Dev Biol. 2010 Nov 15;347(2):348-59.
Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins. Jinno H, Morozova O, Jones KL, Biernaskie JA, Paris M, Hosokawa R, Rudnicki MA, Chai Y, Rossi F, Marra MA, Miller FD. Stem Cells. 2010 Nov;28(11):2027-40.
TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors. Fujitani M, Cancino GI, Dugani CB, Weaver IC, Gauthier-Fisher A, Paquin A, Mak TW, Wojtowicz MJ, Miller FD, Kaplan DR. Curr Biol. 2010 Nov 23;20(22):2058-65.
System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. Morozova O, Vojvodic M, Grinshtein N, Hansford LM, Blakely KM, Maslova A, Hirst M, Cezard T, Morin RD, Moore R, Smith KM, Miller F, Taylor P, Thiessen N, Varhol R, Zhao Y, Jones S, Moffat J, Kislinger T, Moran MF, Kaplan DR, Marra MA. Clin Cancer Res. 2010 Sep 15;16(18):4572-82.
SATB2 augments ΔNp63α in head and neck squamous cell carcinoma. Chung J, Lau J, Cheng LS, Grant RI, Robinson F, Ketela T, Reis PP, Roche O, Kamel-Reid S, Moffat J, Ohh M, Perez-Ordonez B, Kaplan DR, Irwin MS. EMBO Rep. 2010 Oct;11(10):777-83.
White matter repair: skin-derived precursors as a source of myelinating cells. Biernaskie J, Miller FD. Can J Neurol Sci. 2010 Sep;37 Suppl 2:S34-41.
2009 PUBLICATIONS
HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells. Pietras A, Hansford LM, Johnsson AS, Bridges E, Sjölund J, Gisselsson D, Rehn M, Beckman S, Noguera R, Navarro S, Cammenga J, Fredlund E, Kaplan DR, Påhlman S. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16805-10.
CCM2 mediates death signaling by the TrkA receptor tyrosine kinase. Harel L, Costa B, Tcherpakov M, Zapatka M, Oberthuer A, Hansford LM, Vojvodic M, Levy Z, Chen ZY, Lee FS, Avigad S, Yaniv I, Shi L, Eils R, Fischer M, Brors B, Kaplan DR, Fainzilber M. Neuron. 2009 Sep 10;63(5):585-91.
p63 antagonizes p53 to promote the survival of embryonic neural precursor cells. Dugani CB, Paquin A, Fujitani M, Kaplan DR, Miller FD. J Neurosci. 2009 May 20;29(20):6710-21.
Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells. Gauthier-Fisher A, Lin DC, Greeve M, Kaplan DR, Rottapel R, Miller FD. Nat Neurosci. 2009 Jun;12(6):735-44.
In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model. Zhang L, Smith KM, Chong AL, Stempak D, Yeger H, Marrano P, Thorner PS, Irwin MS, Kaplan DR, Baruchel S. Neoplasia. 2009 May;11(5):426-35.
Costello syndrome H-Ras alleles regulate cortical development. Paquin A, Hordo C, Kaplan DR, Miller FD. Dev Biol. 2009 Jun 15;330(2):440-51.
Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair. Lavoie JF, Biernaskie JA, Chen Y, Bagli D, Alman B, Kaplan DR, Miller FD. Stem Cells Dev. 2009 Jul-Aug;18(6):893-906.
SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells. Biernaskie J, Paris M, Morozova O, Fagan BM, Marra M, Pevny L, Miller FD. Cell Stem Cell. 2009 Dec 4;5(6):610-23.
TAp63 prevents premature aging by promoting adult stem cell maintenance. Su X, Paris M, Gi YJ, Tsai KY, Cho MS, Lin YL, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, Flores ER. Cell Stem Cell. 2009 Jul 2;5(1):64-75.
Home at last: neural stem cell niches defined. Miller FD, Gauthier-Fisher A. Cell Stem Cell. 2009 Jun 5;4(6):507-10.
Isolation, expansion, and differentiation of mouse skin-derived precursors. Fernandes KJ, Miller FD. Methods Mol Biol. 2009;482:159-70.
2008 PUBLICATIONS
p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer’s disease. Wetzel MK, Naska S, Laliberté CL, Rymar VV, Fujitani M, Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AF, Miller FD, Kaplan DR. Neuron. 2008 Sep 11;59(5):708-21.
Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phentoype. Bisson N, Tremblay M, Robinson F, Kaplan DR, Trusko SP, Moss T. Cell Cycle. 2008 Apr 1;7(7):909-16.
Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Singh KK, Park KJ, Hong EJ, Kramer BM, Greenberg ME, Kaplan DR, Miller FD. Nat Neurosci. 2008 Jun;11(6):649-58.
Rap1 is involved in the signal transduction of myelin-associated glycoprotein. Taniguchi J, Fujitani M, Endo M, Kubo T, Fujitani M, Miller FD, Kaplan DR, Yamashita T. Cell Death Differ. 2008 Feb;15(2):408-19.
Regenerating your senses: multiple roles for neurogenesis in the adult brain. Frankland PW, Miller FD. Nat Neurosci. 2008 Oct;11(10):1124-6.
Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential. Fernandes KJ, Toma JG, Miller FD. Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):185-98. Review.
2007 PUBLICATIONS
Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Hansford LM, McKee AE, Zhang L, George RE, Gerstle JT, Thorner PS, Smith KM, Look AT, Yeger H, Miller FD, Irwin MS, Thiele CJ, Kaplan DR. Cancer Res. 2007 Dec 1;67(23):11234-43.
Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development. Bartkowska K, Paquin A, Gauthier AS, Kaplan DR, Miller FD. Development. 2007 Dec;134(24):4369-80.
Developing with BDNF: a moving experience. Kaplan DR, Miller FD. Neuron. 2007 Jul 5;55(1):1-2.
Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome. Gauthier AS, Furstoss O, Araki T, Chan R, Neel BG, Kaplan DR, Miller FD. Neuron. 2007 Apr 19;54(2):245- 62.
AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Quevedo C, Kaplan DR, Derry WB. Curr Biol. 2007 Feb 6;17(3):286-92.
To die or not to die: neurons and p63. Miller FD, Kaplan DR. Cell Cycle. 2007 Feb 1;6(3):312-7. Epub 2007 Feb 3. Review.
Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma. Lau L, Hansford LM, Cheng LS, Hang M, Baruchel S, Kaplan DR, Irwin MS. Oncogene. 2007 Mar 22;26(13):1920-31. Epub 2006 Sep 18.
Riding the waves: neural and nonneural origins for mesenchymal stem cells. Miller FD. Cell Stem Cell. 2007 Aug 16;1(2):129-30.
Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury. Biernaskie J, Sparling JS, Liu J, Shannon CP, Plemel JR, Xie Y, Miller FD, Tetzlaff W. J Neurosci. 2007 Sep 5;27(36):9545-59.
Timing is everything: making neurons versus glia in the developing cortex. Miller FD, Gauthier AS. Neuron. 2007 May 3;54(3):357-69. Review.
2006 PUBLICATIONS
An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth. Naska S, Park KJ, Hannigan GE, Dedhar S, Miller FD, Kaplan DR. J Neurosci. 2006 Dec 20;26(51):13344-56
APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, Miller FD, Kaplan DR. Mol Cell Biol. 2006 Dec;26(23):8928-41. Epub 2006 Sep 25
The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons. Hibbert AP, Kramer BM, Miller FD, Kaplan DR. Mol Cell Neurosci. 2006 Aug;32(4):387-402. Epub 2006 Jul 14.
The p53 family in nervous system development and disease. Jacobs WB, Kaplan DR, Miller FD. J Neurochem. 2006 Jun;97(6):1571-84. Review.
Analysis of the neurogenic potential of multipotent skin-derived precursors. Fernandes KJ, Kobayashi NR, Gallagher CJ, Barnabé-Heider F, Aumont A, Kaplan DR, Miller FD. Exp Neurol. 2006 Sep;201(1):32-48. Epub 2006 May 5.
When a motor goes bad: a kinesin regulates neuronal survival. Kaplan DR, Miller FD. Cell. 2006 Apr 21;125(2):224-6.
Isolation of skin-derived precursors (SKPs) and differentiation and enrichment of their Schwann cell progeny. Biernaskie JA, McKenzie IA, Toma JG, Miller FD. Nat Protoc. 2006;1(6):2803-12.
Skin-derived precursors generate myelinating Schwann cells for the injured and dysmyelinated nervous system. McKenzie IA, Biernaskie J, Toma JG, Midha R, Miller FD. J Neurosci. 2006 Jun 14;26(24):6651-60.
Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. Volosin M, Song W, Almeida RD, Kaplan DR, Hempstead BL, Friedman WJ. J Neurosci. 2006 Jul 19;26(29):7756-66.
2005 PUBLICATIONS
p63 is an essential proapoptotic protein during neural development. Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, Keyes WM, Mills AA, Miller FD, Kaplan DR. Neuron. 2005 Dec 8;48(5):743-56.
Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1. Barnabé-Heider F, Wasylnka JA, Fernandes KJ, Porsche C, Sendtner M, Kaplan DR, Miller FD. Neuron. 2005 Oct 20;48(2):253-65.
TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism. Lavoie JF, Lesauteur L, Kohn J, Wong J, Furtoss O, Thiele CJ, Miller FD, Kaplan DR. J Biol Chem. 2005 Aug 12;280(32):29199-207. Epub 2005 Jun 16.
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Torkin R, Lavoie JF, Kaplan DR, Yeger H. Mol Cancer Ther. 2005 Jan;4(1):1-11.
CCAAT/enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo. Paquin A, Barnabé-Heider F, Kageyama R, Miller FD. J Neurosci. 2005 Nov 16;25(46):10747-58.
A transcriptional role for C/EBP beta in the neuronal response to axonal injury. Nadeau S, Hein P, Fernandes KJ, Peterson AC, Miller FD. Mol Cell Neurosci. 2005 Aug;29(4):525-35.
Isolation and characterization of multipotent skin-derived precursors from human skin. Toma JG, McKenzie IA, Bagli D, Miller FD. Stem Cells. 2005 Jun-Jul;23(6):727-37
Activity regulates positive and negative neurotrophin-derived signals to determine axon competition. Singh KK, Miller FD. Neuron. 2005 Mar 24;45(6):837-45.
Role for Runx1 in the proliferation and neuronal differentiation of selected progenitor cells in the mammalian nervous system. Theriault FM, Nuthall HN, Dong Z, Lo R, Barnabe-Heider F, Miller FD, Stifani S. J Neurosci. 2005 Feb 23;25(8):2050-61.
2004 PUBLICATIONS
A dermal niche for multipotent adult skin-derived precursor cells. Fernandes KJ, McKenzie IA, Mill P, Smith KM, Akhavan M, Barnabé-Heider F, Biernaskie J, Junek A, Kobayashi NR, Toma JG, Kaplan DR, Labosky PA, Rafuse V, Hui CC, Miller FD. Nat Cell Biol. 2004 Nov;6(11):1082-93. Erratum in: Nat Cell Biol. 2005 May;7(5):531.
The invulnerability of adult neurons: a critical role for p73. Walsh GS, Orike N, Kaplan DR, Miller FD. J Neurosci. 2004 Oct 27;24(43):9638-47.
Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. Lee AF, Ho DK, Zanassi P, Walsh GS, Kaplan DR, Miller FD. J Neurosci. 2004 Oct 13;24(41):9174-84.
Neuronal MEK is important for normal fear conditioning in mice. Shalin SC, Zirrgiebel U, Honsa KJ, Julien JP, Miller FD, Kaplan DR, Sweatt JD. J Neurosci Res. 2004 Mar 15;75(6):760-70.
Neurobiology: a move to sort life from death. Kaplan DR, Miller FD. Nature. 2004 Feb 26;427(6977):798-9. No abstract available.
Neuronal survival and p73/p63/p53: a family affair. Jacobs WB, Walsh GS, Miller FD. Neuroscientist. 2004 Oct;10(5):443-55. Review.
SRC regulates actin dynamics and invasion of malignant glial cells in three dimensions. Angers-Loustau A, Hering R, Werbowetski TE, Kaplan DR, Del Maestro RF. Mol Cancer Res. 2004 Nov;2(11):595-605.
ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. Subramaniam S, Zirrgiebel U, von Bohlen Und Halbach O, Strelau J, Laliberté C, Kaplan DR, Unsicker K., J Cell Biol. 2004 May 10;165(3):357-69. Epub 2004 May 3.
2003 PUBLICATIONS
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. Marsh HN, Dubreuil CI, Quevedo C, Lee A, Majdan M, Walsh GS, Hausdorff S, Said FA, Zoueva O, Kozlowski M, Siminovitch K, Neel BG, Miller FD, Kaplan DR. J Cell Biol. 2003 Dec 8;163(5):999-1010.
Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse. Atwal JK, Singh KK, Tessier-Lavigne M, Miller FD, Kaplan DR. J Neurosci. 2003 Aug 20;23(20):7602-9.
Signaling mechanisms underlying dendrite formation. Miller FD, Kaplan DR. Curr Opin Neurobiol. 2003 Jun;13(3):391-8. Review.
Axon growth inhibition: signals from the p75 neurotrophin receptor. Kaplan DR, Miller FD. Nat Neurosci. 2003 May;6(5):435-6. No abstract available.
TrkB receptor signaling regulates developmental death dynamics, but not final number, of retinal ganglion cells. Pollock GS, Robichon R, Boyd KA, Kerkel KA, Kramer M, Lyles J, Ambalavanar R, Khan A, Kaplan DR, Williams RW, Frost DO. J Neurosci. 2003 Nov 5;23(31):10137-45.
Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1. Nguyen MD, Boudreau M, Kriz J, Couillard-Després S, Kaplan DR, Julien JP. J Neurosci. 2003 Mar 15;23(6):2131-40.
Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways. Barnabé-Heider F, Miller FD. J Neurosci. 2003 Jun 15;23(12):5149-60.
2002 PUBLICATIONS
Neurobiology. TRK makes the retrograde. Miller FD, Kaplan DR. Science. 2002 Feb 22;295(5559):1471-3
N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. Wartiovaara K, Barnabe-Heider F, Miller FD, Kaplan DR. J Neurosci. 2002 Feb 1;22(3):815-24.
Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway. Jaboin J, Kim CJ, Kaplan DR, Thiele CJ. Cancer Res. 2002 Nov 15;62(22):6756-63.
The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism. Makris C, Voisin L, Giasson E, Tudan C, Kaplan DR, Meloche S. Oncogene. 2002 Nov 7;21(51):7891-6.
Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes. Senger DL, Tudan C, Guiot MC, Mazzoni IE, Molenkamp G, LeBlanc R, Antel J, Olivier A, Snipes GJ, Kaplan DR. Cancer Res. 2002 Apr 1;62(7):2131-40.
An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis. Ménard C, Hein P, Paquin A, Savelson A, Yang XM, Lederfein D, Barnabé-Heider F, Mir AA, Sterneck E, Peterson AC, Johnson PF, Vinson C, Miller FD. Neuron. 2002 Nov 14;36(4):597-610.
p73 is required for survival and maintenance of CNS neurons. Pozniak CD, Barnabé-Heider F, Rymar VV, Lee AF, Sadikot AF, Miller FD. J Neurosci. 2002 Nov 15;22(22):9800-9.
Signaling mechanisms underlying reversible, activity-dependent dendrite formation. Vaillant AR, Zanassi P, Walsh GS, Aumont A, Alonso A, Miller FD. Neuron. 2002 Jun 13;34(6):985-98.
Thyroid hormone-dependent regulation of Talpha1 alpha-tubulin during brain development. Lorenzo PI, Ménard C, Miller FD, Bernal J. Mol Cell Neurosci. 2002 Mar;19(3):333-43.